tag:blogger.com,1999:blog-55415002024-03-19T18:00:30.888+09:00BigHominid's Hairy Chasms"Oh beauty, who dost betwixt thy fever'd buttocks my beleaguer'd skull embrace..."Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.comBlogger20967125tag:blogger.com,1999:blog-5541500.post-41138092869863932932024-03-19T18:00:00.010+09:002024-03-19T18:00:00.139+09:00losing the Latino vote<p>Many—if not most—Latinos who are legitimately in the US <i>do not</i> want open borders:</p>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/71pu6kGY_eI?si=mLjV5-B-Su8hIRAj" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-83469195228403355902024-03-19T13:00:00.011+09:002024-03-19T13:00:00.449+09:00Roland Fryer redux<p>Amala comments:</p>
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<p>How biased is the research on racial motivation in police violence?</p><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-60687630630625387652024-03-19T12:12:00.003+09:002024-03-19T12:12:42.529+09:00victory! (we hope)<p>It is done. The toilet's floater valve has been replaced, and the misbehavior has disappeared. Before, the tank would fill until the "balloon" kicked in* and tipped the valve to the "off" position, then the water would start up again for no apparent reason until the tank was overflowing out through the flush handle. At a guess, the floater valve was just old. Replacing the assembly was a matter of watching <a href="https://youtu.be/H5G4OeIDXMk?si=sdPTUDJfKRRPyA0i">a 90-second-long tutorial</a>, then grunting as I got into awkward positions (with my paunch in the way) to do all that unscrewing and re-screwing... et voilà—with a new valve assembly, the toilet seems to be working fine. I flushed the tank several times to be sure, and everything seems to be working. To minimize the Murphy, I'll check on everything again in a week, then if I remember, in a month. Meanwhile, I'll be on the lookout for stray drips. For the moment, though, it seems I can do my business in relative peace. Praise Cthulhu! How shall I celebrate this minor victory?</p><p>__________</p><p>*On the modern valve I got, it's not a balloon like in the old toilets. It's basically an inverted plastic cup that traps air beneath it and <i>acts</i> like a balloon. The assembly I pulled out was the same. No balloons anywhere.</p><p><br /></p><p><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-39527941790019353402024-03-19T08:00:00.012+09:002024-03-19T08:00:00.245+09:00Fani Willis and the historical pattern of corruption<p>How many times does this bitch get let off the hook?</p>
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<p>Everyone's too scared of holding a black woman accountable. But <i>whites</i> are privileged, right?</p><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-24176811020735705622024-03-19T03:30:00.013+09:002024-03-19T03:30:00.137+09:00President Shambles: 46 minutes in<p style="text-align: left;">We now get to the "fax machine" part of the exchange, in which Joe Biden (so his critics claim) seems unfamiliar with fax machines. Page 41 of the transcript:</p><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px; text-align: left;"><p style="text-align: left;"><span style="font-family: courier;">[0 : 46:41.8]</span></p><p style="text-align: left;"><span style="font-family: courier;">MR. HUR: And now I have a similar set of questions with respect to the lake house in Wilmington. So, when you were serving as Vice President, did you have -- did you bring classified material with you from the West Wing or the Naval Observatory to the lake house?</span></p><p style="text-align: left;"><span style="font-family: courier;">PRESIDENT BIDEN: Occasionally, because I did a lot of business from there. If you're in there for 99 hours, or whatever the hell you were, with 375 people, or whatever the number was -- I'm teasing you.</span></p><p style="text-align: left;"><span style="font-family: courier;">(Laughter)</span></p><p style="text-align: left;"><span style="font-family: courier;">PRESIDENT BIDEN: You left everything in place. I just hope you didn't find any risqué pictures of my wife in a bathing suit. Which you probably did. She's beautiful. But all kidding aside, I have a library, and the library has a -- two filing cabinets in it, and it has built into the walls -- when I built that home, built into the walls, a space for a copy machine, for a -- what do you call it, when they send these --</span></p><p style="text-align: left;"><span style="font-family: courier;">MR. SISKEL: Fax machine.</span></p><p style="text-align: left;"><span style="font-family: courier;">PRESIDENT BIDEN: Fax machine. I have shelves that I have, I have binders like this in it that I put together that aren't classified. They're about speeches that I made on this matter, speeches I made on that matter.</span></p><p style="text-align: left;"><span style="font-family: courier;">PRESIDENT BIDEN: I just warn you all, never make one great eulogy, because you get asked to do everybody's eulogy.</span></p><p style="text-align: left;"><span style="font-family: courier;">(Laughter)</span></p></blockquote><div><p style="text-align: left;">So Biden glitched on the term "fax machine," but I've glitched like that before myself, blanking on a specific phrase. This in itself isn't nearly as earth-shaking as the previous geezer moment. It certainly doesn't mean he doesn't know what a fax machine is; it's more that he simply couldn't find the word for it in his rusty, creakily turning Rolodex of mental vocabulary.</p><p style="text-align: left;">Not the best look, but not the worst look. I really could've done without the visual of Taco Jill in a bathing suit, though. "Risqué" to whom? You can <i>keep</i> her, Joe!</p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p></div>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com1tag:blogger.com,1999:blog-5541500.post-33300550194677041082024-03-19T03:00:00.005+09:002024-03-19T03:00:00.144+09:00humor: woke chick tries to report a crime<center><iframe width="560" height="315" src="https://www.youtube.com/embed/lz48Ffjil4Q?si=hCgQiJRmUHDJcMvv" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-78487725982959890822024-03-18T23:54:00.000+09:002024-03-18T23:54:28.721+09:00tomorrow, we slay the dragon<p style="text-align: left;">My toilet stuff came today, and tomorrow morning, I'll replace my floater-valve assembly. It won't solve the leakage problem at the base of my toilet, but I'm hoping like hell that it solves the constantly-running-water problem inside the toilet tank. Manually closing the main valve every time I use the toilet kinda sucks. Unboxing:</p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4grEyK3pxuL9dmk0saQOio52LCLYZjT0u5oxJ4Eb0EfAMy49n7aHOQ3OUiQV_U48D8HDgygDJjX7dlgGNumjXr87y3fqwG3euD0LnuMn89sKeg5DHMke1CXHNWa89GzEfYN9IEpy2psbz0V-uByVtIvzIOXj8YDNWpwh3Sx8daUrXNCTbZg15/s2554/20240318_203803.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="1893" data-original-width="2554" height="474" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi4grEyK3pxuL9dmk0saQOio52LCLYZjT0u5oxJ4Eb0EfAMy49n7aHOQ3OUiQV_U48D8HDgygDJjX7dlgGNumjXr87y3fqwG3euD0LnuMn89sKeg5DHMke1CXHNWa89GzEfYN9IEpy2psbz0V-uByVtIvzIOXj8YDNWpwh3Sx8daUrXNCTbZg15/w640-h474/20240318_203803.jpg" width="640" /></a></div><br /><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiBdNAmWJLQkj8jyQTY9mUj4kpFVNj9ootEE_JCzh8NfCkgDIdKmxRMM0EtpB_IaVUzhXgoEYeSE5wmS7OVofDWI15cUJYertLkVm0fylgLuICIUmwGv3fbVuqFgOHQWNxnswj36lX2a68y8uDjjnJCQh_9lLFtsH1zCIPJoptItudDr-dy_0JV/s4032/20240318_204047.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="4032" data-original-width="2268" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiBdNAmWJLQkj8jyQTY9mUj4kpFVNj9ootEE_JCzh8NfCkgDIdKmxRMM0EtpB_IaVUzhXgoEYeSE5wmS7OVofDWI15cUJYertLkVm0fylgLuICIUmwGv3fbVuqFgOHQWNxnswj36lX2a68y8uDjjnJCQh_9lLFtsH1zCIPJoptItudDr-dy_0JV/w360-h640/20240318_204047.jpg" width="360" /></a></div><br /><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhPbOrja81MYHEnlamKuM1x4Z1AN18V1FyKK_jiamLh52G-P4qZekSnLQWOLhFIHCT0m7v-GMgduK-mWke05D_33AY9BhSzxWG0ns9-27fIeA9pmh66p5yJVSgmWuc7RD0PvR8rrO5aWhgSZOiE0YQmTWoMohZgaMH9Mp11CZF-qmJWgTto40V5/s3780/20240318_204114.jpg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="3780" data-original-width="2268" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhPbOrja81MYHEnlamKuM1x4Z1AN18V1FyKK_jiamLh52G-P4qZekSnLQWOLhFIHCT0m7v-GMgduK-mWke05D_33AY9BhSzxWG0ns9-27fIeA9pmh66p5yJVSgmWuc7RD0PvR8rrO5aWhgSZOiE0YQmTWoMohZgaMH9Mp11CZF-qmJWgTto40V5/w384-h640/20240318_204114.jpg" width="384" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">all the pieces laid out</td></tr></tbody></table><br /><table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEijUhD0kqUsdPgtSZeydt7EwjSzyDHTXD_1eQcRPkKq1OvwSAMVXSyWSmCPGKRL2MU0hCYLA1J82_w-4DU89iRFdFZAImrkhKxuxUv711kiQWswMtOxzCcjtVFtaxU8FiQVxKWyIBc_s4lp4PMcSNXZZDol85R0iqX1IL55XTQNQL28NxNerJSZ/s4032/20240318_204117.jpg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="4032" data-original-width="2268" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEijUhD0kqUsdPgtSZeydt7EwjSzyDHTXD_1eQcRPkKq1OvwSAMVXSyWSmCPGKRL2MU0hCYLA1J82_w-4DU89iRFdFZAImrkhKxuxUv711kiQWswMtOxzCcjtVFtaxU8FiQVxKWyIBc_s4lp4PMcSNXZZDol85R0iqX1IL55XTQNQL28NxNerJSZ/w360-h640/20240318_204117.jpg" width="360" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">the main piece that needs replacing</td></tr></tbody></table><br /><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-7815034567230247152024-03-18T23:00:00.034+09:002024-03-18T23:00:00.135+09:00be careful, righties, re: employing Carlin as your weapon of choice<p>For righties to get behind George Carlin, they have to forget that Carlin was a liberal even if he did score points against the woke left with rants like the one below:</p>
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<p>Righties are more apt to quote lefties when the lefties make rightie points (e.g., quoting Bill Maher or Bill Burr or Ana Kasparian when it's convenient which, yes, I've done, too) than vice versa, but that often results in a kind of ideological Stockholm Syndrome. Maybe the idea is to virtuously avoid the genetic fallacy to show how open minded one is, but when leftie-quoting becomes a <i>pattern</i> of behavior, something pernicious may be at play.</p><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-44295177362354820212024-03-18T18:00:00.006+09:002024-03-18T18:00:00.136+09:00the proposed TikTok "ban" is not a ban<center><iframe width="560" height="315" src="https://www.youtube.com/embed/EqSp2cq0HqM?si=rLappD5J-We09qJI" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-13418524523134585652024-03-18T16:15:00.005+09:002024-03-18T18:54:32.058+09:00the "bloodbath" hoax<p>When in doubt, quote Trump out of context, then run around screaming as if your head were on fire.* This is a favorite "tactic" of the left, but with X/Twitter no longer suppressing the right, corrections are possible, and sooner than before. So, no: in his recent speech, Trump wasn't saying there'd be a "bloodbath" if he's not elected. He was talking specifically about the auto industry, something that very few news outlets were honest enough to point out:</p>
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<p>While we're at it, someone put together a supercut of leftist media outlets all using the term "bloodbath." As usual: <i>they</i> can say it, but the right can't.</p>
<center><blockquote class="twitter-tweet"><p dir="ltr" lang="en">SUPERCUT! <br /><br />Trump critics would never use a term like “bloodbath” <a href="https://t.co/6dSTMwsfJa">pic.twitter.com/6dSTMwsfJa</a></p>— Tom Elliott (@tomselliott) <a href="https://twitter.com/tomselliott/status/1769455728941547695?ref_src=twsrc%5Etfw">March 17, 2024</a></blockquote> <script async="" charset="utf-8" src="https://platform.twitter.com/widgets.js"></script></center>
<p>Hypocrisy and projection are all the left has. I hope people remember nonsense like this come election time. This is how the left operates, and how it's been operating for a long time.</p><p>__________</p><p>*And the left loves to accuse the <i>right</i> of fearmongering. More projection.</p><br /><br />Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com1tag:blogger.com,1999:blog-5541500.post-36623229047233544652024-03-18T13:00:00.013+09:002024-03-18T13:00:00.140+09:00Judge "McWussy," says Doug<p>Judge McAfee's attempt to be Solomonic has led to derision from the right, who see him as a spineless squish worried about reelection to his post:</p>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/0pdYa8xxbcQ?si=YDtl50YwsEONHlOB" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-81995446518596362382024-03-18T08:00:00.012+09:002024-03-18T08:00:00.350+09:00EVs again<p style="text-align: left;"><a href="https://www.lifesitenews.com/news/electric-cars-pollute-1850-times-more-than-fuel-based-vehicles-study-finds/">Headline</a>:</p><div style="text-align: left;"><b>Electric cars pollute 1,850 times more than fuel-based vehicles, study finds</b></div><i>The 2022 U.K.-based Emissions Analytics study found that after driving both a gas and electric car 1,000 miles, the number of particles collected from the EV was vastly greater than the gasoline-powered car.</i><br /><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px; text-align: left;"><p style="text-align: left;">A 2022 study found that electric vehicles (EVs), which left-leaning governments in Canada, the United States, and elsewhere are pushing on the population, pollute at a rate far higher than their gasoline or diesel-powered counterparts.</p><p style="text-align: left;">The 2022 <a href="https://www.emissionsanalytics.com/news/gaining-traction-losing-tread">stud</a>y from the U.K.-based Emissions Analytics group found that during a 1,000-mile journey, EVs release 1,850 times more pollutants into the surrounding environment than gas-powered vehicles due to the heavier weight, which eats through tires.</p><p style="text-align: left;">While many think of emissions from exhaust, tire wear plays a significant role in emitting pollutants. The synthetic rubber used to create tires includes certain chemicals that get released into the air, and EVs are significantly heavier than conventional cars because of massive lithium batteries.</p><p style="text-align: left;">Overall, EVs weigh about 30 percent more than gas-powered vehicles and cost thousands more to make and buy. These issues are in addition to the fact that they are not suitable in colder climates (such as Canada and the northern U.S.), offer poor range and long charging times (especially in cold weather), and have batteries that take tremendous resources to make and are hard to recycle.</p><p style="text-align: left;">Both the government of Canada under Prime Minister Justin Trudeau and the government of the United States under President Joe Biden are hoping to ban, or severely limit, the sale of new gasoline-powered cars after 2035 despite these deficiencies. The EU (European Union) also has an EV mandate in place for the same year.</p></blockquote><p style="text-align: left;">EVs don't fill me with confidence. And it's no surprise to see upside-down and backwards priorities from our illustrious leaders, Trudeau and Biden.</p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com2tag:blogger.com,1999:blog-5541500.post-80743480848654068272024-03-18T03:00:00.067+09:002024-03-18T03:00:00.245+09:00President Shambles: barely 12 minutes in<p>From the Hur-Biden transcript, page 12:</p><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px;"><p class="p1" style="color: #2f2f2f; font-feature-settings: normal; font-kerning: auto; font-optical-sizing: auto; font-stretch: normal; font-variant-alternates: normal; font-variant-east-asian: normal; font-variant-numeric: normal; font-variant-position: normal; font-variation-settings: normal; line-height: normal; margin: 0px; text-align: left;"><span style="font-family: courier;">PRESIDENT BIDEN<span class="s1" style="color: #0c0c0c;">: </span>And you learn </span><span style="font-family: courier;">more from </span><span class="s2" style="color: #3e3e3e; font-family: courier;">that </span><span style="font-family: courier;">as you </span><span class="s2" style="color: #3e3e3e; font-family: courier;">learn </span><span style="font-family: courier;">anything else</span><span class="s1" style="color: #0c0c0c; font-family: courier;">. </span><span style="font-family: courier;">So one of my </span><span class="s1" style="color: #0c0c0c; font-family: courier;">-- </span><span style="font-family: courier;">and </span><span class="s2" style="color: #3e3e3e; font-family: courier;">the President </span><span style="font-family: courier;">gave me <i>carte blanche</i> to engage any member </span><span style="font-family: courier;">of the Administration. So, for example, we used to have </span><span style="font-family: courier;">meetings at NIH where there was a</span><span class="s1" style="color: #0c0c0c; font-family: courier;">l</span><span style="font-family: courier;">l the medical -- what </span><span class="s2" style="color: #3e3e3e; font-family: courier;">I </span><span style="font-family: courier;">did, I made sure that the Defense Department was </span><span class="s1" style="color: #0c0c0c; font-family: courier;">t</span><span style="font-family: courier;">here</span><span class="s1" style="color: #0c0c0c; font-family: courier;">. </span><span style="font-family: courier;">I </span><span style="font-family: courier;">made sure that the, </span><span class="s2" style="color: #3e3e3e; font-family: courier;">the </span><span class="s1" style="color: #0c0c0c; font-family: courier;">-</span><span style="font-family: courier;">- NASA was </span><span class="s2" style="color: #3e3e3e; font-family: courier;">there</span><span class="s1" style="color: #0c0c0c; font-family: courier;">. </span><span style="font-family: courier;">NASA knows more </span><span class="s2" style="color: #3e3e3e; font-family: courier;">about</span><span class="s1" style="color: #0c0c0c; font-family: courier;">, </span><span style="font-family: courier;">about dealing with some of the things that </span><span class="s2" style="color: #3e3e3e; font-family: courier;">have </span><span style="font-family: courier;">to do </span><span style="font-family: courier;">when working that cancer. Many people </span><span class="s2" style="color: #3e3e3e; font-family: courier;">die </span><span style="font-family: courier;">trying to -</span><span class="s1" style="color: #0c0c0c; font-family: courier;">- </span><span style="font-family: courier;">when </span><span style="font-family: courier;">they kill the cancer, they use a proton </span><span class="s2" style="color: #3e3e3e; font-family: courier;">-</span><span class="s1" style="color: #0c0c0c; font-family: courier;">- </span><span style="font-family: courier;">anyway.</span></p></blockquote><p>We're barely 12 minutes into this conversation, and we're already seeing signs of how Joe Biden's mind will wander into the weeds. Nothing here is damning, but it's a harbinger of what's to come. We'll be seeing plenty of sentences that end with, "...anyway."</p><p>It's true that Robert Hur may have instigated the above thoughts on cancer research by referring to Biden's book, titled <i>Promise Me, Dad</i>. (Up to now, Hur has made no direct reference to Beau. Joe Biden did that on his own.) "Promise me" is supposedly a quote from Beau Biden, said while he was sick with glioblastoma, in an attempt to make sure Joe Biden would run for office, presumably as a way to keep the Obama legacy alive.</p><p>NB: I've chosen to title this series "President Shambles." I was inspired by John McCrarey's suggestion to title the series "The Walking Brain Dead." John's suggestion evokes zombies, and most zombies <i>shamble</i> from place to place. Biden the shambling zombie has left our country <i>in a shambles</i>... and thus was President Shambles born.</p><p><br /></p><p><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com1tag:blogger.com,1999:blog-5541500.post-70986079889500491322024-03-17T23:00:00.002+09:002024-03-17T23:02:36.672+09:00the Joetato is out to lunch<p>It's been weird watching Joe Rogan come around to Trump:</p>
<center><script>!function(r,u,m,b,l,e){r._Rumble=b,r[b]||(r[b]=function(){(r[b]._=r[b]._||[]).push(arguments);if(r[b]._.length==1){l=u.createElement(m),e=u.getElementsByTagName(m)[0],l.async=1,l.src="https://rumble.com/embedJS/uaf7gh"+(arguments[1].video?'.'+arguments[1].video:'')+"/?url="+encodeURIComponent(location.href)+"&args="+encodeURIComponent(JSON.stringify([].slice.apply(arguments))),e.parentNode.insertBefore(l,e)}})}(window, document, "script", "Rumble");</script>
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<p>Well, Joe's <i>going</i>. Is he <i>gone</i> yet?</p><br /><br />Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-61772939456546017902024-03-17T18:30:00.002+09:002024-03-17T18:30:00.131+09:00too late for Mom, but maybe not for others<p style="text-align: left;">A new therapy for glioblastoma (GBM), the most common and most aggressive brain tumor, may finally be here.* It's too late to help Mom, but maybe others can benefit.</p><p style="text-align: left;"><a href="https://www.sciencealert.com/breakthrough-therapy-obliterates-deadly-brain-tumor-in-days">Headline</a>:</p><p style="text-align: left;"><b>Breakthrough Therapy Obliterates Deadly Brain Tumor in Days</b></p><blockquote style="border: none; margin: 0px 0px 0px 40px; padding: 0px; text-align: left;"><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">Brain scans of a 72-year-old man diagnosed with a highly aggressive form of <a class="lar_link lar_link_outgoing" data-linkid="73077" data-postid="121898" href="https://www.sciencealert.com/cancer" rel="nofollow" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;" target="_self">cancer</a> known as a <a href="https://en.wikipedia.org/wiki/Glioblastoma" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;">glioblastoma</a> have revealed a remarkable regression in his tumor's size within days of receiving an infusion of an innovative new treatment.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">Though the outcomes of two other participants with similar diagnoses were somewhat less positive, the case's success still bodes well for the search for a way to effectively cure what is currently an incurable disease.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">Glioblastomas <a href="https://www.sciencealert.com/brain-tumors-can-rewire-the-brain-and-we-just-found-out-how" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;">are typically about as deadly</a> as cancers can get. Emerging from supporting cells inside the central nervous system, they can rapidly develop into malignant masses that claim <a href="https://www.ncbi.nlm.nih.gov/books/NBK470003/" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;">up to 95 percent of patient lives</a> within five years.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">Researchers from Mass General Cancer Centre in the US suspected a treatment based on the patient's own immune system, known as <a href="https://www.cancer.gov/about-cancer/treatment/research/car-t-cells" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;">CAR T-cell therapy</a>, might succeed where other therapies fail.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">Having been approved for treating blood cancers, <a href="https://www.sciencealert.com/newly-discovered-t-cells-could-rid-late-stage-cancer-patients-of-tumors" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;">CAR T-cell therapy's impressive ability</a> to sniff out cancerous cells just might present advantages in destroying glioblastomas.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">Patient T-cells are collected and re-engineered to recognize identifying surface markers on the outside of cancer cells before being returned via an infusion, meaning CAR T-cell therapy is somewhat like employing a local bounty hunter to slip silently through the alleys in search of a wanted villain.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">One marker prevalent across a range of glioblastomas, a <a href="https://academic.oup.com/neuro-oncology/article/16/suppl_8/viii20/1421893" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;">mutated variant</a> of a protein called epidermal growth factor receptor (EGFR), has potential as a target for CAR T-cell treatment. Unfortunately glioblastomas wear a variety of disguises that make the re-engineering process a real challenge.</span></p><p style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; background-color: white; border: 0px solid currentcolor; box-sizing: border-box; color: #333333; letter-spacing: -0.4px; line-height: 27px; margin: 0px 0px 0.8rem; overflow-wrap: break-word;"><span style="font-family: arial;">To overcome this, researchers have found a way to encourage CAR T-cells to also produce <a class="lar_link lar_link_outgoing" data-linkid="73081" data-postid="121898" href="https://www.sciencealert.com/antibody" rel="nofollow" style="--tw-blur: var(--tw-empty,/*!*/ /*!*/); --tw-border-opacity: 1; --tw-brightness: var(--tw-empty,/*!*/ /*!*/); --tw-contrast: var(--tw-empty,/*!*/ /*!*/); --tw-drop-shadow: var(--tw-empty,/*!*/ /*!*/); --tw-filter: var(--tw-blur) var(--tw-brightness) var(--tw-contrast) var(--tw-grayscale) var(--tw-hue-rotate) var(--tw-invert) var(--tw-saturate) var(--tw-sepia) var(--tw-drop-shadow); --tw-grayscale: var(--tw-empty,/*!*/ /*!*/); --tw-hue-rotate: var(--tw-empty,/*!*/ /*!*/); --tw-invert: var(--tw-empty,/*!*/ /*!*/); --tw-rotate: 0; --tw-saturate: var(--tw-empty,/*!*/ /*!*/); --tw-scale-x: 1; --tw-scale-y: 1; --tw-sepia: var(--tw-empty,/*!*/ /*!*/); --tw-skew-x: 0; --tw-skew-y: 0; --tw-text-opacity: 1; --tw-transform: translateX(var(--tw-translate-x)) translateY(var(--tw-translate-y)) rotate(var(--tw-rotate)) skewX(var(--tw-skew-x)) skewY(var(--tw-skew-y)) scaleX(var(--tw-scale-x)) scaleY(var(--tw-scale-y)); --tw-translate-x: 0; --tw-translate-y: 0; border-color: rgba(229,231,235,var(--tw-border-opacity)); border-image: initial; border-style: solid; border-width: 0px 0px 1px; box-sizing: border-box; line-height: 27px; margin-bottom: 0.8rem; text-decoration: inherit;" target="_self">antibodies</a> that seek out non-variant EGFRs. While these proteins aren't usually expressed by brain cells, they are found on cancer cells, providing an extra identifying feature for the recruited bounty hunters.</span></p></blockquote><p style="text-align: left;">This could be something. Or someone just got lucky.</p><p style="text-align: left;">__________</p><p style="text-align: left;">*Famous victims of this tumor include Ted Kennedy, John McCain, and Beau Biden.</p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-87526194628418782852024-03-17T18:00:00.006+09:002024-03-17T19:20:47.779+09:00a knockout blonde<p style="text-align: left;"><a href="https://youtube.com/shorts/v8k6pkRRDtM?si=IJ_ZS-mXq2S2BoWN"></a></p><div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiUlrvCTNVvuvJMg6TcsuQ_HbNFb0SfAUyxUBLPXotCUG-Bo0ZdC16QxdtdQEOwAGrTT5Nvj53DZ2Tm_nqpxxy0mplKXykuwETYeCYS55nCfiayNKDy6lhNkJvoiSONmfbdfqqKeWXZc1X16tydL8T9F0n5pYMk1fTqxzel4_uZxpbGxbiE81nk/s2133/240314BrutalKnockout.jpg" style="margin-left: 1em; margin-right: 1em;"><img border="0" data-original-height="2133" data-original-width="1345" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEiUlrvCTNVvuvJMg6TcsuQ_HbNFb0SfAUyxUBLPXotCUG-Bo0ZdC16QxdtdQEOwAGrTT5Nvj53DZ2Tm_nqpxxy0mplKXykuwETYeCYS55nCfiayNKDy6lhNkJvoiSONmfbdfqqKeWXZc1X16tydL8T9F0n5pYMk1fTqxzel4_uZxpbGxbiE81nk/w404-h640/240314BrutalKnockout.jpg" width="404" /></a></div><br /><a href="https://youtube.com/shorts/v8k6pkRRDtM?si=oQACxQk-_8nRWSoK">Another brutal, beautiful knockout</a>, this time via roundhouse kick in a women's-kickboxing match. The recipient of the kick didn't have her guard up high enough. Not the best roundhouse form I've ever seen, but the kick did what it was supposed to do.<p></p><p style="text-align: left;">ADDENDUM: I forgot to add the link! Sorry. Added now.</p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-34992648231135282472024-03-17T13:30:00.003+09:002024-03-17T17:16:39.277+09:00Slainte!<table align="center" cellpadding="0" cellspacing="0" class="tr-caption-container" style="margin-left: auto; margin-right: auto;"><tbody><tr><td style="text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgPhbeBBCdNUZ_nr-n_Bhz4NP-YaxjfYSZX3LzAQgO7dISK50z5Gieaa8oyheMH078o9nisSdJ1Go2PPKgnx1uapO3KXbB_eiG6svqqjJ-k9R7zXKL34azecyZghtWFwfgPwIK1DQd_VfxcNrRFTCFEU6INdyPKE815oKJit1YYNkKq1dccSWvd/s1024/833151adb7484bfd91c0ca3d10c9ccd1.jpeg" style="margin-left: auto; margin-right: auto;"><img border="0" data-original-height="1024" data-original-width="1024" height="640" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgPhbeBBCdNUZ_nr-n_Bhz4NP-YaxjfYSZX3LzAQgO7dISK50z5Gieaa8oyheMH078o9nisSdJ1Go2PPKgnx1uapO3KXbB_eiG6svqqjJ-k9R7zXKL34azecyZghtWFwfgPwIK1DQd_VfxcNrRFTCFEU6INdyPKE815oKJit1YYNkKq1dccSWvd/w640-h640/833151adb7484bfd91c0ca3d10c9ccd1.jpeg" width="640" /></a></td></tr><tr><td class="tr-caption" style="text-align: center;">She might be A.I.-rish. Her left hand and arm are strangely connected. Or maybe she's not Irish at all, but Inuit.</td></tr></tbody></table><p style="clear: both; text-align: left;">Happy Saint Patrick's Day!</p><p style="clear: both; text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-69889923061097726582024-03-17T13:00:00.001+09:002024-03-17T13:00:00.242+09:00"ethical" veganism<p style="text-align: left;">I don't know whether <a href="https://youtube.com/shorts/QEauJuVo6WA?si=chsLfjg4OVFQOtEz">I agree with this</a>. It feels as if it needs to be unpacked further. My own argument against ethical veganism is future-oriented: vegans presume that the vegetal world isn't sentient, but with more and more studies of plant sentience seeming to suggest that plants may, in some limited way, possess a level of consciousness, that argument is on the edge of fraying and disappearing. What are your thoughts?</p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-48230597406532681832024-03-17T08:00:00.001+09:002024-03-17T08:00:00.130+09:00celebrate the day with buttholes!<center><iframe width="560" height="315" src="https://www.youtube.com/embed/wYfGsFOKwy4?si=lgkYSTGAQMlvPPZz" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-70710754502948037412024-03-17T03:00:00.023+09:002024-03-17T03:00:00.252+09:00"white rural rage": the new imaginary enemyAnd a happy Saint Patrick's Day to you! Especially to all of you angry white people!<br><br>
<a href="https://youtube.com/shorts/AuZ-wEbxPKQ?si=ttLpqSKXITIxObFs">Freitas with his thoughts.</a>
<p>Here's Styx:</p>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/26iLbiys7Ts?si=8ebGxMY1dmj6sEgV" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center>
<p>And here's the angriest white person—Matt Walsh:</p>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/LXdWFuH_XTQ?si=ptSm_QN-wnXZg3Lr" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com1tag:blogger.com,1999:blog-5541500.post-76983297607256795382024-03-17T02:28:00.001+09:002024-03-17T09:24:42.006+09:00if it's not one thing, it's another<p style="text-align: left;">I came home Friday evening to the sound of a constant drip-drip-dripping noise coming from my bathroom. Grimacing, I turned on the light and peeked in, which is how I saw a leak from out of the side of my toilet tank, right where the flush handle was. I lifted off the tank's lid to see the water level was way too high. I flushed the toilet experimentally; the water in the tank descended; the lid at the bottom of the tank closed up; the water began filling again until the floater valve's "balloon" rose to a certain point, and the water flowing into the tank shut off... until it didn't. The water flow started up again, despite the balloon's position, and the tank kept filling until it overflowed again.</p><p style="text-align: left;">Sighing, I closed the water valve connected to the wall, washed my hands, then went to consult the YouTube gurus. Most of the basic videos about this problem said the cause could be one of two things: a bad floater valve or a bad lid. The lid in my toilet tank seemed fine, and the most common recommendation for the floater valve was to manually adjust the balloon downward to make the water flow shut off earlier. Another suggestion was to open up the floater valve's top and de-gunk it in case there were any buildups of calcium, etc. inside it. There was nothing to de-gunk when I checked, and I adjusted the floater valve's balloon downward. I opened the wall valve and let the water fill again. The lower balloon did indeed cause the water flow to shut off earlier, but as before, the shutoff was only temporary, and the water started flowing again. The other recommendation I saw was that, if these two fixes aren't working (lid and floater valve), replace the floater valve with a new one. So I have one on order.</p><p style="text-align: left;">In the meantime, I'm manually shutting off the water every time I use the bathroom. I flush; I let the tank refill; I shut off the wall valve. In a few days, the new part will arrive, and I'll try to replace the floater valve myself. I could, in theory, call the toilet repairman back; I still have <a href="https://bighominid.blogspot.com/2023/08/my-toilet-is-still-leaking.html">that other leaking problem</a>, so he could fix both in a single visit. I email my HR department when I have a plumbing problem, and thus far, I haven't been charged anything (unlike when my A/C needs work), so I could do the lazy thing and let a pro handle both of my problems. But part of me wants to get in there and do the valve repair myself. It doesn't look that hard, and I need to get handier, anyway. Just in case some hot woman with an overinflated chest and nipples pulsing in seductive Morse Code asks me to work on her pipes.</p><p style="text-align: left;"><br /></p><p style="text-align: left;"><br /></p>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com1tag:blogger.com,1999:blog-5541500.post-80045806778094988342024-03-16T23:00:00.006+09:002024-03-16T23:00:00.136+09:00comedy sketch: Wolverine's powers<center><iframe width="560" height="315" src="https://www.youtube.com/embed/-vQ2RVqJCNM?si=pxmZSG3LP6TQ5VLi" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-31467566706281488432024-03-16T18:00:00.024+09:002024-03-16T18:00:00.134+09:00touchy, touchy<p>Does Tim Pool have a point about this guy?</p>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/O-YB7P-qm2c?si=nN5EvPCbkNn412Jp" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center>
<p>I think what Pool is saying is that the whole trans thing is easy for most of us to tolerate until trans people's demands become unreasonable. One thing I've observed is that, when trans women (i.e., biological males) flip out about being "misgendered," their reaction often strikes me as a moment of <i>masculine</i> anger, not feminine anger. This is not true for all trans people.</p><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-46633061991259643432024-03-16T13:00:00.001+09:002024-03-16T13:00:00.146+09:00even Italy hates Biden<center><iframe width="560" height="315" src="https://www.youtube.com/embed/6cYyCE2KnQ0?si=s7-X2jE52vsXEA7V" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0tag:blogger.com,1999:blog-5541500.post-71245862720052170202024-03-16T12:24:00.001+09:002024-03-16T12:25:04.003+09:00Viva Frei on the Scott McAfee judgment re: Fani Willis<p>Shit don't make no sense.</p>
<center><iframe width="560" height="315" src="https://www.youtube.com/embed/oJNVOQH8gjE?si=D222oUNgEfd_FrlW" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" allowfullscreen></iframe></center><br><br><br><br>Kevin Kimhttp://www.blogger.com/profile/01328790917314282058noreply@blogger.com0